Fermi's contribution to the world of quantum mechanics is vast, but his input to the paradox bearing his name is slight. It's said that he engaged in a conversation in the summer of 1950. Michael Hart put the idea to paper in 1975 that civilizations reach a point of singularity wherein they self-destruct, so the chances of two civilizations of similar technological advancement existing in the same galactic neighbourhood are too slim to be potentially possible.
We can clearly see we're careering towards such a singularity, ourselves, on this planet - the unstoppable race towards Doomsday not slowing up any time soon, about to cross the inescapable line with you and me as bystanders, watching it happen in slow motion, like the spagettification of a lifetime into the last dense drop of quark-gluon plasma a Singularity has to become before... before the laws of physics break down and we don't know what happens next.
What if IT happens in the next 12 years? Prince Charles gives us 18 months to Irreversible Calamity.
Here we are then, merry observant spaghettifees watching renormalised disaster strike from all sides and helpless to do anything about it. Except think. We can think all we want, intelligent beings that can comprehend a Universe. Think ourselves into being a bit more double-slit, where choices are made in advance of probability and wave forms can take you for a different kind of ride.